Morten Bro Nielsen
 
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Deformation
Registration
Growth
Cranio-facial
Active models
 

Ph.D. - Medical Image Registration and Surgery Simulation

Projects

Real-time deformation for surgery simulation

Real-time deformable models, using finite element models of linear elasticity, are developed for use in surgery simulation. The time consumption of the finite element method is reduced dramatically, by the use of condensation techniques, explicit inversion of the stiffness matrix, and the use of selective matrix vector multiplication.

Medical image registration

A new and faster algorithm for non-rigid registration using viscous fluid models is presented. This algorithm replaces the core part of the original algorithm with multi-resolution convolution using a new filter, which implements the linear elasticity operator. Using the filter results in a speedup of at least an order of magnitude. Use of convolution hardware is expected to improve the performance even more.

Mandibular growth for time registration of mandibles

Non-rigid registration using a physically valid model of bone growth is also presented. Using medical knowledge about the growth processes of the mandibular bone, a registration algorithm for time sequence images of the mandible is developed. Since this registration algorithm models the actual development of the mandible, it is possible to simulate the development.

3D visualization - the Mvox software

Mvox is a software package for medical researchers that want to analyze volumetric medical images in 3D. Using advanced rendering algorithms and the computer graphics hardware in SGI workstations, Mvox produces eye-opening 3D visualizations.

Cranio-facial surgery simulation

Planning of cranio-facial surgery is difficult and at the same time essential to the outcome. In this project I developed a methodology for modeling the deformation of soft tissue in the face of a cranio-facial patient in response to changes in topology of the underlying bones.

2D and 3D modeling using Active Nets/Cubes

The topic of this project is deformable models in general. I have implemented a range of the physical models described in the literature: 2D & 3D active contours and 2D active nets.

Rigid medical image registration
Rigid image registration using voxel similarity measures are reviewed, and new measures based on Grey Level Co-occurrence Matrices (GLCM) are introduced. These measures are evaluated extensively using CT, MR, and cryo-section images from the Visible Human data set. The results show that mutual information remains the best generally applicable measure. But for specific modality combinations the new GLCM measures show considerable promise.

 

 

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